Paliperidone is a well known dopamine antagonist of the atypical antipsychotic class. In present study paliperidone was formulated as matrix type sustained release tablets using natural polymers. Gum exudates are among the oldest natural polymers. They are already being used as thickening and stabilizing agent from last several years. The plant derived polymers comply with many requirements of pharmaceutical excipients. The aim of sustained release formulation is to reduce the frequency of dosing. Tablets were prepared by direct compression method. The optimized formulations contain paliperidone as active ingredient and guar gum, xanthum gum and Acacia gum are used as polymers. The evaluation parameters include the thickness, weight variation test, drug content, hardness, friability and in-vitro release studies. Based on the results of in-vitro studies it was concluded that the natural polymers can be used as an efficient matrix former to provide sustained release of paliperidone. The release of paliperidone was prolonged for 20 hrs, indicating the usefulness of the formulations for once daily dosage forms. Thus the reducing frequency of dosing increases patient compliance.
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